[GO:0017076] |
purine nucleotide binding |
91 |
91 |
[GO:0003676] |
nucleic acid binding |
88 |
88 |
[GO:0032555] |
purine ribonucleotide binding |
81 |
81 |
[GO:0004872] |
receptor activity |
75 |
75 |
[GO:0004690] |
cyclic nucleotide-dependent protein kinase activity |
68 |
68 |
[GO:0004691] |
cAMP-dependent protein kinase activity |
67 |
67 |
[GO:0016491] |
oxidoreductase activity |
67 |
67 |
[GO:0008270] |
zinc ion binding |
64 |
64 |
[GO:0030554] |
adenyl nucleotide binding |
63 |
63 |
[GO:0005102] |
receptor binding |
57 |
57 |
[GO:0032559] |
adenyl ribonucleotide binding |
53 |
53 |
[GO:0005215] |
transporter activity |
52 |
52 |
[GO:0008233] |
peptidase activity |
46 |
46 |
[GO:0070011] |
peptidase activity, acting on l-amino acid peptides |
43 |
43 |
[GO:0003677] |
DNA binding |
43 |
43 |
[GO:0004888] |
transmembrane receptor activity |
40 |
40 |
[GO:0005509] |
calcium ion binding |
39 |
39 |
[GO:0022892] |
substrate-specific transporter activity |
39 |
39 |
[GO:0004687] |
myosin light chain kinase activity |
38 |
38 |
[GO:0030528] |
transcription regulator activity |
37 |
37 |
[GO:0022857] |
transmembrane transporter activity |
36 |
36 |
[GO:0022891] |
substrate-specific transmembrane transporter activity |
35 |
35 |
[GO:0030234] |
enzyme regulator activity |
35 |
35 |
[GO:0005506] |
iron ion binding |
33 |
33 |
[GO:0004175] |
endopeptidase activity |
33 |
33 |
[GO:0003700] |
transcription factor activity |
32 |
32 |
[GO:0015075] |
ion transmembrane transporter activity |
30 |
30 |
[GO:0019001] |
guanyl nucleotide binding |
28 |
28 |
[GO:0005198] |
structural molecule activity |
28 |
28 |
[GO:0004857] |
enzyme inhibitor activity |
26 |
26 |
[GO:0016788] |
hydrolase activity, acting on ester bonds |
26 |
26 |
[GO:0008324] |
cation transmembrane transporter activity |
25 |
25 |
[GO:0009055] |
electron carrier activity |
24 |
24 |
[GO:0004930] |
G-protein coupled receptor activity |
24 |
24 |
[GO:0003723] |
RNA binding |
23 |
23 |
[GO:0005126] |
cytokine receptor binding |
22 |
22 |
[GO:0016874] |
ligase activity |
22 |
22 |
[GO:0048037] |
cofactor binding |
20 |
20 |
[GO:0016817] |
hydrolase activity, acting on acid anhydrides |
19 |
19 |
[GO:0003735] |
structural constituent of ribosome |
19 |
19 |
[GO:0005125] |
cytokine activity |
18 |
18 |
[GO:0030414] |
peptidase inhibitor activity |
18 |
18 |
[GO:0050662] |
coenzyme binding |
17 |
17 |
[GO:0016757] |
transferase activity, transferring glycosyl groups |
17 |
17 |
[GO:0030246] |
carbohydrate binding |
17 |
17 |
[GO:0008092] |
cytoskeletal protein binding |
16 |
16 |
[GO:0022890] |
inorganic cation transmembrane transporter activity |
16 |
16 |
[GO:0016746] |
transferase activity, transferring acyl groups |
16 |
16 |
[GO:0016879] |
ligase activity, forming carbon-nitrogen bonds |
16 |
16 |
[GO:0000287] |
magnesium ion binding |
15 |
15 |
[GO:0008237] |
metallopeptidase activity |
15 |
15 |
[GO:0016614] |
oxidoreductase activity, acting on CH–OH group of donors |
15 |
15 |
[GO:0022804] |
active transmembrane transporter activity |
15 |
15 |
[GO:0019955] |
cytokine binding |
14 |
14 |
[GO:0017171] |
serine hydrolase activity |
14 |
14 |
[GO:0046906] |
tetrapyrrole binding |
14 |
14 |
[GO:0016616] |
oxidoreductase activity, acting on the CH–OH group of donors, NAD or NADP as acceptor |
14 |
14 |
[GO:0016747] |
transferase activity, transferring acyl groups other than amino-acyl groups |
14 |
14 |
[GO:0008528] |
peptide receptor activity, G-protein coupled |
14 |
14 |
[GO:0003779] |
actin binding |
14 |
14 |
[GO:0004252] |
serine-type endopeptidase activity |
13 |
13 |
[GO:0016705] |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
13 |
13 |
[GO:0004497] |
monooxygenase activity |
12 |
12 |
[GO:0042578] |
phosphoric ester hydrolase activity |
12 |
12 |
[GO:0008234] |
cysteine-type peptidase activity |
11 |
11 |
[GO:0046873] |
metal ion transmembrane transporter activity |
11 |
11 |
[GO:0008289] |
lipid binding |
11 |
11 |
[GO:0016791] |
phosphatase activity |
11 |
11 |
[GO:0050660] |
FAD binding |
10 |
10 |
[GO:0015078] |
hydrogen ion transmembrane transporter activity |
10 |
10 |
[GO:0016758] |
transferase activity, transferring hexosyl groups |
10 |
10 |
[GO:0004867] |
serine-type endopeptidase inhibitor activity |
10 |
10 |
[GO:0004428] |
inositol or phosphatidylinositol kinase activity |
10 |
10 |
[GO:0016798] |
hydrolase activity, acting on glycosyl bonds |
10 |
10 |
[GO:0005516] |
calmodulin binding |
9 |
9 |
[GO:0016810] |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
9 |
9 |
[GO:0042623] |
ATPase activity, coupled |
9 |
9 |
[GO:0001871] |
pattern binding |
9 |
9 |
[GO:0016776] |
phosphotransferase activity, phosphate group as acceptor |
9 |
9 |
[GO:0005179] |
hormone activity |
9 |
9 |
[GO:0070851] |
growth factor receptor binding |
9 |
9 |
[GO:0004197] |
cysteine-type endopeptidase activity |
9 |
9 |
[GO:0005057] |
receptor signaling protein activity |
9 |
9 |
[GO:0004950] |
chemokine receptor activity |
9 |
9 |
[GO:0004222] |
metalloendopeptidase activity |
9 |
9 |
[GO:0043565] |
sequence-specific DNA binding |
9 |
9 |
[GO:0005216] |
ion channel activity |
8 |
8 |
[GO:0016853] |
isomerase activity |
8 |
8 |
[GO:0000826] |
inositol pyrophosphate synthase activity |
8 |
8 |
[GO:0019842] |
vitamin binding |
8 |
8 |
[GO:0005539] |
glycosaminoglycan binding |
8 |
8 |
[GO:0005529] |
sugar binding |
8 |
8 |
[GO:0005066] |
transmembrane receptor protein tyrosine kinase signaling protein activity |
8 |
8 |
[GO:0020037] |
heme binding |
8 |
8 |
[GO:0004356] |
glutamate-ammonia ligase activity |
8 |
8 |
[GO:0005507] |
copper ion binding |
7 |
7 |
[GO:0016209] |
antioxidant activity |
7 |
7 |
[GO:0008238] |
exopeptidase activity |
7 |
7 |
[GO:0008009] |
chemokine activity |
7 |
7 |
[GO:0016860] |
intramolecular oxidoreductase activity |
7 |
7 |
[GO:0004721] |
phosphoprotein phosphatase activity |
7 |
7 |
[GO:0015291] |
secondary active transmembrane transporter activity |
7 |
7 |
[GO:0016563] |
transcription activator activity |
6 |
6 |
[GO:0005244] |
voltage-gated ion channel activity |
6 |
6 |
[GO:0008201] |
heparin binding |
6 |
6 |
[GO:0031420] |
alkali metal ion binding |
6 |
6 |
[GO:0046983] |
protein dimerization activity |
6 |
6 |
[GO:0015082] |
di-, tri-valent inorganic cation transmembrane transporter activity |
6 |
6 |
[GO:0004312] |
fatty-acid synthase activity |
6 |
6 |
[GO:0042802] |
identical protein binding |
6 |
6 |
[GO:0016684] |
oxidoreductase activity, acting on peroxide as acceptor |
6 |
6 |
[GO:0016829] |
lyase activity |
5 |
5 |
[GO:0008047] |
enzyme activator activity |
5 |
5 |
[GO:0003924] |
GTPase activity |
5 |
5 |
[GO:0004091] |
carboxylesterase activity |
5 |
5 |
[GO:0015399] |
primary active transmembrane transporter activity |
5 |
5 |
[GO:0005261] |
cation channel activity |
5 |
5 |
[GO:0019904] |
protein domain specific binding |
5 |
5 |
[GO:0004694] |
eukaryotic translation initiation factor 2alpha kinase activity |
5 |
5 |
[GO:0016627] |
oxidoreductase activity, acting on the CH–CH group of donors |
5 |
5 |
[GO:0031406] |
carboxylic acid binding |
5 |
5 |
[GO:0042803] |
protein homodimerization activity |
5 |
5 |
[GO:0004518] |
nuclease activity |
5 |
5 |
[GO:0019899] |
enzyme binding |
5 |
5 |
[GO:0003774] |
motor activity |
5 |
5 |
[GO:0008430] |
selenium binding |
5 |
5 |
[GO:0004725] |
protein tyrosine phosphatase activity |
5 |
5 |
[GO:0015293] |
symporter activity |
5 |
5 |
[GO:0004713] |
protein tyrosine kinase activity |
5 |
5 |
[GO:0046915] |
transition metal ion transmembrane transporter activity |
4 |
4 |
[GO:0008135] |
translation factor activity, nucleic acid binding |
4 |
4 |
[GO:0008134] |
transcription factor binding |
4 |
4 |
[GO:0010857] |
calcium-dependent protein kinase activity |
4 |
4 |
[GO:0050661] |
NADP or NADPH binding |
4 |
4 |
[GO:0060589] |
nucleoside-triphosphatase regulator activity |
4 |
4 |
[GO:0008373] |
sialyltransferase activity |
4 |
4 |
[GO:0004896] |
cytokine receptor activity |
4 |
4 |
[GO:0008083] |
growth factor activity |
4 |
4 |
[GO:0016709] |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
4 |
4 |
[GO:0004576] |
oligosaccharyl transferase activity |
4 |
4 |
[GO:0008509] |
anion transmembrane transporter activity |
4 |
4 |
[GO:0051540] |
metal cluster binding |
4 |
4 |
[GO:0004177] |
aminopeptidase activity |
4 |
4 |
[GO:0016765] |
transferase activity, transferring alkyl or aryl (other than methyl) groups |
4 |
4 |
[GO:0015929] |
hexosaminidase activity |
4 |
4 |
[GO:0016741] |
transferase activity, transferring one-carbon groups |
4 |
4 |
[GO:0004129] |
cytochrome-c oxidase activity |
4 |
4 |
[GO:0004521] |
endoribonuclease activity |
4 |
4 |
[GO:0051287] |
NAD or NADH binding |
3 |
3 |
[GO:0005385] |
zinc ion transmembrane transporter activity |
3 |
3 |
[GO:0004774] |
succinate-CoA ligase activity |
3 |
3 |
[GO:0004090] |
carbonyl reductase (NADPH) activity |
3 |
3 |
[GO:0005249] |
voltage-gated potassium channel activity |
3 |
3 |
[GO:0008757] |
S-adenosylmethionine-dependent methyltransferase activity |
3 |
3 |
[GO:0005160] |
transforming growth factor beta receptor binding |
3 |
3 |
[GO:0008235] |
metalloexopeptidase activity |
3 |
3 |
[GO:0005275] |
amine transmembrane transporter activity |
3 |
3 |
[GO:0019840] |
isoprenoid binding |
3 |
3 |
[GO:0019838] |
growth factor binding |
3 |
3 |
[GO:0005128] |
erythropoietin receptor binding |
3 |
3 |
[GO:0016801] |
hydrolase activity, acting on ether bonds |
3 |
3 |
[GO:0016701] |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
3 |
3 |
[GO:0003712] |
transcription cofactor activity |
3 |
3 |
[GO:0015144] |
carbohydrate transmembrane transporter activity |
3 |
3 |
[GO:0003995] |
acyl-CoA dehydrogenase activity |
3 |
3 |
[GO:0004869] |
cysteine-type endopeptidase inhibitor activity |
3 |
3 |
[GO:0031402] |
sodium ion binding |
3 |
3 |
[GO:0019888] |
protein phosphatase regulator activity |
3 |
3 |
[GO:0016651] |
oxidoreductase activity, acting on NADH or NADPH |
3 |
3 |
[GO:0004180] |
carboxypeptidase activity |
3 |
3 |
[GO:0030695] |
GTPase regulator activity |
3 |
3 |
[GO:0010181] |
FMN binding |
3 |
3 |
[GO:0003743] |
translation initiation factor activity |
3 |
3 |
[GO:0016861] |
intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
3 |
3 |
[GO:0004522] |
pancreatic ribonuclease activity |
3 |
3 |
[GO:0015294] |
solute:cation symporter activity |
3 |
3 |
[GO:0016790] |
thiolester hydrolase activity |
3 |
3 |
[GO:0008026] |
ATP-dependent helicase activity |
3 |
3 |
[GO:0030145] |
manganese ion binding |
3 |
3 |
[GO:0008417] |
fucosyltransferase activity |
3 |
3 |
[GO:0008194] |
UDP-glycosyltransferase activity |
3 |
3 |
[GO:0008199] |
ferric iron binding |
3 |
3 |