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A global perturbation, which brings the system to Region II, may lead to ectopic silencing and reduction in the overall strength of silencing. This would particularly in affect silenced regions that do not have well-defined boundary elements. This is because of rampant spread of silencing and titration of ambient SIR proteins. The unperturbed system is represented by the top half of the figure and the perturbed system, by the bottom half. BE = Boundary elements.
