Table 4.
Prevalence of respiratory impairment, stratified by GOLD, ATS/ERS, and LMS criteria, as well as by study sample
| Spirometric Threshold | Airflow Limitation | Restrictive-pattern | ||
|---|---|---|---|---|
| No. (%) | ||||
| NHANES III N=1,548 |
ARIC N=7,972 |
NHANES III N=1,548 |
ARIC N=7,972 |
|
| GOLDa | 344 (22.2) | 1,723 (21.6) | 147 (9.5) | 387 (4.9) |
| ATS/ERSb | 268 (17.3) | 1,256 (15.8) | 167 (10.8) | 452 (5.7) |
| LMSc | 243 (15.7) | 1,142 (14.3) | 111 (7.2) | 314 (3.9) |
Abbreviations: NHANES III, Third National Health and Nutrition Examination Survey; ARIC, Atherosclerosis Risk in Communities Study; GOLD, Global Initiative for Obstructive Lung Disease; ATS/ERS, American Thoracic Society/European Respiratory Society; LMS, Lambda-Mu-Sigma method; ATS/ERS-LLN5, ATS/ERS defined lower limit of normal; LMS-LLN5, LMS defined lower limit of normal; FEV1/FVC, forced expiratory volume in 1-second to forced vital capacity.
Based on a fixed-ratio threshold, with airflow limitation defined by a FEV1/FVC<0.70, while restrictive-pattern is defined by a FEV1/FVC≥0.70 and FVC<80% predicted. Percent predicted is calculated as [(measured ÷ predicted) * 100].
Based on a threshold of ATS/ERS-LLN5, with airflow limitation defined by a FEV1/FVC<ATS/ERS-LLN5, while restrictive-pattern is defined by a FEV1/FVC≥ATS/ERS-LLN5 and FVC<ATS/ERS-LLN5.
Based on a threshold of LMS-LLN5, with airflow limitation defined by a FEV1/FVC<LMS-LLN5, while restrictive-pattern is defined by a FEV1/FVC≥LMS-LLN5 and a FVC<LMS-LLN5.