Table 5.
Multivariate associations of plasma cell neoplasm risk.
| Characteristic | Adjusted SIR ratio | 95% lower limit | 95% upper limit | P-value |
|---|---|---|---|---|
| Multivariate model | ||||
| Male sex | 1.14 | 0.74 | 1.77 | 0.54 |
| Age at transplant, years | 0.002* | |||
| 0–34 | 4.02 | 1.45 | 11.14 | |
| 35–49 | 1.58 | 0.98 | 2.54 | |
| 50–64 | 1.00 | |||
| 65+ | 0.75 | 0.44 | 1.28 | |
| Race/ethnicity | 0.06 | |||
| White | 1.00 | |||
| Black | 0.53 | 0.30 | 0.92 | |
| Hispanic | 0.72 | 0.37 | 1.39 | |
| Asian/Pacific Islander | 1.46 | 0.59 | 3.63 | |
| EBV serology | 0.04 | |||
| Positive | 1.00 | |||
| Negative | 2.76 | 1.26 | 6.06 | |
| Missing | 1.00 | 0.61 | 1.66 | |
| BMI | 0.07* | |||
| Underweight | 0.29 | 0.04 | 2.08 | |
| Normal weight | 1.00 | |||
| Overweight | 0.64 | 0.41 | 0.99 | |
| Obese | 0.58 | 0.33 | 1.02 | |
| Models adjusted for sex and age | ||||
| Cholestatic liver disease, liver recipients | 3.12 | 1.27 | 7.69 | 0.02 |
| Coronary artery disease, heart recipients | 0.48 | 0.22 | 1.05 | 0.07 |
| Monoclonal antibody (plasmacytoma) | 3.32 | 1.51 | 7.28 | 0.008 |
| MMF (plasmacytoma) | 0.42 | 0.20 | 0.87 | 0.01 |
Notes
Abbreviations: BMI body mass index, EBV Epstein-Barr virus, MMF mycophenolate mofetil, SIR standardized incidence ratio.
*
P-value is for test of trend. Other p-values are tests of heterogeneity.