This figure is reprinted from our previous publication in Endocrinology (Ostrander et al, 2006), documenting attenuation of HPA axis responses to acute stress following CVS exposure in the same animals used for c-fos mRNA determinations. Chronically stressed animals tested at 4 d and 7 d recovery exhibit an attenuated plasma corticosterone response to EPM exposure. Plasma corticosterone levels (mean + SEM) at 20 min, 40 min, and 60 min following the end of a 5 min exposure to an EPM at A) 16 h recovery, B) 4 d recovery, C) 7 d recovery, or D) 30 d recovery from CVS. * = p < 0.05 versus control group. Reprinted with permission (Ostrander et al, Endocrinology 147: 2008-2017 (2006)).