Table 3.
Hematology and Chemistries (Mean Value ± SD)1
| Treatment Condition |
WBC2 (103/ml) |
HgB (g/dl) |
PLT (103/ml) |
NEU (% WBC) |
LYM (% WBC) |
MON (% WBC) |
BUN (mg/dl) |
Creatinine (mg/dl) |
Alk Phos (U/L) |
AST (U/L) |
ALT (U/L) |
CPK (U/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Untreated | 2.1 ± 0.8 | 12.1 ± 0.8 | 1003 ± 84 | 27.32 ± 4.27 | 65.68 ± 6.54 | 1.10 ± 0.44 | 32 ± 8 | 0.37 ± 0.08 | 90 ± 13 | 115 ± 81 | 34 ± 19 | 573 ± 536 |
| HPPH–only | 3.4 ± 1.7 | 10.8 ± 3.7 | 855 ± 156 | 27.83 ± 8.50 | 67.63 ± 8.94 | 0.90 ± 0.28 | 30 ± 8 | 0.27 ± 0.12 | 81 ± 29 | 95 ± 19 | 203 | 1873 |
| Light–only | 4.8 ± 1.2 | 12.4 ± 0.6 | 918 ± 88 | 23.25 ± 5.54 | 70.82 ± 9.55 | 1.00 ± 0.43 | 26 ± 4 | 0.30 ± 0 | 98 ± 14 | 95 ± 42 | 24 ± 6 | 323 ± 237 |
| PDT | 4.7 ± 1.8 | 7.9 ± 3.4 | 345 ± 2255 | 86.50 ± 7.795 | 7.10 ± 5.375 | 4.03 ± 0.065 | 39 ± 16 | 0.27 ± 0.12 | 59 ± 22 | 1309 ± 4985 | 296 ± 724 | 3178 ± 5984 |
1
Blood collected from tumor-free animals 24 hours after intrathoracic HPPH-PDT to 50 J/cm or the indicated controls; n=3-6 animals except where noted.
2
WBC, White blood cell count; HgB, hemoglobin; PLT, platelet count; NEU, neutrophils; LYM, lymphocytes; MON, monocytes; BUN, blood urea nitrogen; Alk Phos, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CPK, creatine phosphokinase
3
Only 1 sample was available for this condition.
4
Two samples were available for these conditions so comparison to untreated is observational (no statistical tests performed).
5
p < 0.05 for comparison to untreated samples.