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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Pharmacol Res. 2012 Jun 28;66(4):363–373. doi: 10.1016/j.phrs.2012.05.010

Table 1.

Inhibition of Eph receptor interaction with a peptide or ephrin ligands by tea polyphenols

Compound Structure MWa (% Inhib.) EphA4 KYL IC50 ± SEb (μM)
EphA4 KYL EphA4 ephrin-A5 EphA2 ephrin-A5 EphB4 ephrin-B2
2′,2′-bisepigallocatechin monogallate graphic file with name nihms390370t1.jpg 763 80 ndc nd nd nd
2′,2‴-bisepigallocatechin digallate graphic file with name nihms390370t2.jpg 915 76 nd nd nd nd
theaflavin monogallatesd graphic file with name nihms390370t3.jpg 717 70 4.3 ± 0.56
ne = 3		 42 ± 1.5
n = 3		 78 ± 3.2
n = 3		 >200
theaflavin- 3,3′-digallate graphic file with name nihms390370t4.jpg 869 65 nd nd nd nd
epigallocatechin- 3,5-digallate graphic file with name nihms390370t5.jpg 610 58 1.5 ± 0.13
n = 4		 7.4 ± 1.8
n = 6		 40 ± 3.8
n = 2		 90 ± 9.5
n = 2
epigallocatechin- 3-monogallate (EGCG) graphic file with name nihms390370t6.jpg 458 < 40 15 ± 1.8
n = 3		 > 200 > 200 > 200
epigallotechin graphic file with name nihms390370t7.jpg 290 < 40 44 ± 13
n = 2		 > 200 > 200 > 200
epicatechin- 3-monogallate graphic file with name nihms390370t8.jpg 442 < 40 50 ± 6.0
n = 2		 > 200 > 200 > 200
epicatechin graphic file with name nihms390370t9.jpg 306 < 40 190 ± 1.5
n = 2		 > 200 > 200 > 200
a

Molecular weight.

b

Standard error.

c

Not determined.

d

Mixture of theaflavin-3-gallate and theaflavin-3′-gallate (theaflavin-3-gallate is shown).

e

Number of replicates used to calculate the error.