Table 2.

Genetic deletion of NOX2 in murine models of Alzheimer’s and Parkinson’s disease is anti-inflammatory and neuroprotective

Mouse disease model	Effect	References
Alzheimer’s disease
Aβ1-40 superfusion	Gp91−/− mice showed lower ROS and reduced cerebrovascular dysfunction	[181]
Tg2576/Cybb−/− mice	Lack of gp91 protected against neurovascular and behavioral dysfunction	[184]
Parkinson’s disease
Paraquat	Gp91−/− mice showed reduced microglial activation and DA neurotoxicity	[102, 129]
Neuromelanin	Gp91−/− mice showed reduced neuroinflammation and DA neurotoxicity	[99]
LPS	Gp91−/− mice showed reduced microglial activation and DA neurotoxicity	[26]
MPTP	Gp91−/− mice showed microglial activation and DA neurotoxicity	[143, 156]

Genetic ablation of NOX2 in mice is associated with anti-inflammatory and neuroprotective effects in mouse models of Alzheimer’s and Parkinson’s disease

DA dopaminergic, Aβ beta amyloid, LPS Lipopolysaccharide, MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, ROS reactive oxygen species