Table 2.
fMRI activation peaks for the main effects and interactions of 1–0 dot back, 2–0 dot back, and progressive deactivation contrasts across groups (p < 0.05 FWE corrected across whole brain unless otherwise stated).
| Contrast | Group/interaction | Z-score | p-value | Peak coordinates (x, y, z) in MNI space | Anatomical region (BA#) |
|---|---|---|---|---|---|
| 1-0 Dot back | Control | 5.07 | 0.000 | 20, − 70, 66 | R. superior parietal lobe (BA7) |
| 4.63 | 0.000 | 32, 2, 56 | R. middle frontal gyrus (BA6) | ||
| 4.82 | 0.000 | − 28, − 66, 62 | L. superior parietal lobe (BA7) | ||
| 4.52 | 0.000 | − 30, 6, 64 | L. middle frontal gyrus (BA9) | ||
| Left HS | 3.67 | 0.001 | − 26, 12, 66 | L. middle frontal gyrus (BA6) | |
| 3.27 | 0.001 | 20, 14, 62 | R. middle frontal gyrus (BA6) | ||
| Right HS | 4.90 | 0.000 | − 22, 6, 54 | L. Middle frontal gyrus (BA6) | |
| 4.79 | 0.000 | 34, 14, 58 | R. superior frontal gyrus (BA6) | ||
| 4.66 | 0.000 | 38, 22, 44 | R. middle frontal gyrus (BA6) | ||
| Left HS < Controls | 4.02 | 0.001 | 18, − 68, 68 | R. superior parietal lobe (BA7) | |
| 3.82 | 0.001 | − 30, − 66, 64 | L. superior parietal lobe (BA7) | ||
| Right HS < Controls | 3.24 | 0.001 | − 30, − 64, 62 | L. superior parietal lobe (BA7) | |
| 3.02 | 0.005⁎ | 18, − 68, 68 | R. superior parietal lobe (BA7) | ||
| 2-0 Dot back | Controls | 5.50 | 0.000 | 20, − 68, 64 | R. superior parietal lobe (BA7) |
| 5.23 | 0.000 | 28, 8, 64 | R. middle frontal gyrus (BA6) | ||
| 4.70 | 0.000 | − 30, 6, 64 | L. middle frontal gyrus (BA6) | ||
| 3.93 | 0.000 | 34, 24, − 4 | R. inferior frontal gyrus (BA47) | ||
| 3.66 | 0.000 | − 32, 30, − 4 | L. inferior frontal gyrus (BA47) | ||
| Left HS | 5.38 | 0.000 | − 6, − 74, 56 | L. superior parietal lobe (BA7) | |
| 5.36 | 0.000 | 20, 10, 66 | R. superior frontal gyrus (BA6) | ||
| 5.35 | 0.000 | − 22 12 68 | L. superior frontal gyrus (BA6) | ||
| 5.13 | 0.000 | − 36, 28, 32 | L. middle frontal gyrus (BA6) | ||
| 4.98 | 0.000 | 40, 30, 32 | R. middle frontal gyrus (BA6) | ||
| Right HS | 5.52 | 0.000 | − 50, − 56, 54 | L. inferior parietal lobe (BA40) | |
| 5.29 | 0.000 | 40, 26, 40 | R. middle frontal gyrus (BA8) | ||
| 4.94 | 0.000 | − 44, 26, 32 | L. Middle frontal gyrus (BA6) | ||
| Left HS < Controls | 3.76 | 0.000 | 20, − 68, 66 | R. superior parietal lobe (BA7) | |
| Right HS < Controls | 3.34 | 0.000 | 20, − 66, 66 | R. superior parietal lobe (BA7) | |
| Progressive deactivations | Controls | 5.29 | 0.000 | 12, − 104, 14 | L. Occipital Lobe (BA19) |
| 5.14 | 0.000 | 6, − 56, 32 | R. Precuneus | ||
| 4.83 | 0.000 | − 44, − 2, − 18 | L. sup. temporal gyrus (BA22) | ||
| 4.82 | 0.000 | − 8, 60, 36 | L. medial frontal gyrus (BA10) | ||
| 3.89 | 0.000 | 52, − 8, − 2 | R. sup. temporal gyrus (BA22) | ||
| 3.09 | 0.01⁎ | − 28, − 12, − 22 | L. Hippocampus | ||
| 2.37 | 0.01⁎ | 24, − 4, − 22 | R. Hippocampus | ||
| Left HS | 3.33 | 0.000 | 50, − 12, 6 | R. sup. temporal gyrus (BA22) | |
| 3.29 | 0.000 | − 2, 56, − 12 | L. medial frontal gyrus (BA10) | ||
| 3.16 | 0.001 | 22, − 12, − 24 | R. Hippocampus | ||
| 3.03 | 0.001 | 6, − 46, 36 | R. Precuneus | ||
| Right HS | 5.63 | 0.000 | 12, − 104, 6 | R. Occipital Lobe (BA19) | |
| 5.18 | 0.000 | − 4, − 64, 30 | L. Precuneus | ||
| 3.35 | 0.000 | − 2, 66, 8 | L. medial frontal gyrus (BA10) | ||
| 3.35 | 0.000 | − 46, − 18, − 2 | L. sup. temporal gyrus (BA22) | ||
| 2.84 | 0.002⁎ | − 28, − 20, − 20 | L. Hippocampus | ||
| Left HS < Controls | 3.32 | 0.029⁎⁎ | − 8, − 12, 48 | L. Hippocampus | |
| Right HS < Controls | 2.42 | 0.066⁎⁎ | 26, − 4, − 22 | R. Amygdala |
HS = Hippocampal Sclerosis; MNI = Montreal Neurological Institute; BA = Brodmann Area; L = left; R = right.
⁎
p < 0.01 uncorrected.
⁎⁎
p < 0.05 Family-Wise Error corrected after 8 mm sphere small volume correction based on peak activation.