TABLE 1.
Demographic data of kidney donors and recipients
| Variable | PBx | DGF | P | AREJ | P | ABMR | P |
|---|---|---|---|---|---|---|---|
| Number of biopsies | 10 | 14 | N/A | 30 | N/A | 11 | N/A |
| Number of donors | 10 | 13 | N/A | 29 | N/A | 11 | N/A |
| Donor age, yr | 59.5 (54.0; 67.0) | 51.0 (46.0; 64.0) | 0.42 | 54.0 (48.0; 60.0) | 0.18 | 53.0 (44.0; 64.0) | 0.40 |
| Donor sex, F/M | 6/4 | 5/8 | 0.41 | 12/17 | 0.47 | 4/7 | 0.37 |
| Donor source, living/deceased | 6/4 | 0/13 | <0.01a | 3/26 | <0.01a | 0/11 | 0.01a |
| Donor last creatinine, mg/dL | 0.82 (0.69; 0.92) | 0.95 (0.7; 1.4) | 0.17 | 1.00 (0.82; 1.17) | 0.04 | 1.04 (0.7; 1.4) | 0.14 |
| Number of recipients | 10 | 13 | N/A | 29 | N/A | 11 | N/A |
| Recipient sex, F/M | 3/7 | 2/11 | 0.62 | 7/22 | 0.70 | 5/6 | 0.66 |
| Recipient age, yr | 50.8 (41.3; 59.1) | 53.5 (47.2; 65.1) | 0.34 | 49.1 (36.7; 61.3) | 0.86 | 59.9 (47.0; 65.3) | 0.38 |
| Transplant number, 1/2/3/4/5 | 10/0/0/0/0 | 10/1/1/0/1 | 1.00a | 26/3/0/0/0 | 0.56a | 7/2/2/0/0 | 0.09a |
| Cold ischemic time, hr | 1.0 (0.0; 8) | 11.5 (10; 17.5) | <0.01 | 13 (7; 16) | <0.01 | 20 (15; 22) | <0.01 |
| PRA latest, % | 0.0 (0.0; 0.0) | 0.0 (0.0; 5.0) | 0.02 | 3.0 (0.0; 4.0) | <0.01 | 40.0 (3.0; 60.0) | <0.01 |
| Sum of HLA mismatches, 0/1/2/3/4/5 | 0/1/2/4/2/1 | 3/3/1/4/1/1 | 0.57 | 2/2/6/7/10/2 | 0.87 | 0/0/1/5/5/0 | 0.51 |
| Immunosuppression, CNI/else | 9/1 | 12/1 | 1.00a | 23/5 | 0.31a | 11/0 | 1.00a |
| Induction therapy, none/IL-2/ATG | 6/3/1 | 11/1/1 | 0.26a | 23/4/1 | 0.50a | 6/3/2 | 1.00a |
| Time of biopsy, days after transplantation | 104.5 (102; 109.5) | 7 (2; 8) | 16.5 (7; 44.5) | 14 (12; 55.5) |
a
Fisher’s exact test.
Continuous data are provided as median and interquartile range, and categorical data are shown as counts. P values refer to the comparison with PBx.
ABMR, antibody-mediated rejection; AREJ, acute cellular rejection; ATG, antithymocyte globulin; CNI, calcineurin inhibitors; DGF, delayed graft function; HLA, human leukocyte antigen; IL, interleukin; N/A, not applicable; PBx, protocol biopsy; PRA, panel reactive antibody.