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Analyses of brain tissue volume in representative magnetic resonance image (MRI) scans ex vivo (MRI images, A; quantification, B) and corresponding histologic sections (photomicrographs, C; quantification, D) from APPNLh/NLh subjected to controlled cortical impact (CCI) injury and treatment with either vehicle or 3 mg/kg simvastatin for 3 weeks. MRI analysis demonstrates greater tissue preservation in the CCI/drug group. *P<0.05.
