Table 1. Physiologic dataa.
| WT naive | hAβ naive | WT 3 days after CCI | hAβ 3 days after CCI | WT 3 weeks after CCI | hAβ 3 weeks after CCI | hAβ 3 weeks after CCI/veh | hAβ 3 weeks after CCI/simva | |
|---|---|---|---|---|---|---|---|---|
| (n=4) | (n=4) | (n=5) | (n=5) | (n=6) | (n=6) | (n=10) | (n=9) | |
| pH | 7.42±0.02 | 7.4±0.03 | 7.38±0.04 | 7.41±0.03 | 7.44±0.03 | 7.41±0.02 | 7.39±0.03 | 7.4±0.05 |
| PaCO2 | 36.4±2.1 | 35.1±1.8 | 36.1±3 | 36.6±2.1 | 35.6±2.6 | 36.5±4.3 | 37.8±3.85 | 35.6±6.0 |
| PaO2 | 240±12 | 243±8.6 | 244±15.1 | 240±11 | 238.5±9.3 | 245±8.2 | 240.5±9.3 | 231.6±34.2 |
| MABP | 82±11.6 | 89.1±9 | 91.1±13.6 | 77±10 | 81.8±15.1 | 79±12.6 | 86±9 | 83±10.3 |
| Heart rate | 485±65 | 502±112 | 499±83 | 475±75 | 519±92 | 496±55 | 475±121 | 504±94 |
| Weight (g) | 28±2 | 31±1.4 | 31±0.9 | 28±1 | 31±2.1 | 33±1.3 | 29±1.2 | 30±0.6 |
Abbreviations: CCI, controlled cortical impact; MABP, mean arterial blood pressure; veh, vehicle; WT, wild type.
Data were collected before and after perfusion imaging and averaged. All variables were within normal range.
a
Data are mean±SD.