Table 1. ROI analysis and voxel analysis.
|
ROI |
Voxel |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| r | Slope | Outliers % | Median PD | Median CV | r | Slope | Outliers % | Median CV | |
| [11C]DASB (N=209) | |||||||||
| FRTM | 0.958 | 0.969 | 0.80 | 7.488 | 0.191 | — | — | ||
| SRTM | 0.972 | 0.933 | 0.16 | 6.596 | 0.136 | — | — | ||
| Logan RR | 0.956 | 0.703 | 1.59 | 22.603 | 0.111 | — | — | ||
| MRTM | 0.973 | 0.947 | 1.83 | 7.182 | 0.143 | 0.508 | 0.833 | 0.91 | 5.401 |
| [11C]CUMI (N=22) | |||||||||
| FRTM | 0.982 | 0.986 | 1.05 | 4.914 | 0.045 | — | — | ||
| SRTM | 0.994 | 0.958 | 1.05 | 6.103 | 0.039 | — | — | ||
| MRTM | 0.702 | 0.989 | 0.70 | 5.215 | 0.059 | — | — | ||
| MRTMo | — | — | — | — | — | 0.902 | 0.703 | 1.20 | 0.692 |
| LEGA RR | — | — | — | — | — | 0.947 | 0.901 | 1.60 | 0.733 |
| [11C]BTA (N=74) | |||||||||
| SRTM | 0.705 | 0.886 | 0.23 | 24.288 | 0.056 | — | — | ||
| MRTM | 0.649 | 0.868 | 0.23 | 20.967 | 0.120 | — | — | ||
| MRTM2 (average) | 0.984 | 0.872 | 0.68 | 19.556 | 0.088 | — | — | ||
| MRTM2 (median) | 0.983 | 0.878 | 0.68 | 19.582 | 0.088 | — | — | ||
| LEGA RR | — | — | — | — | — | 0.990 | 0.863 | 0.00 | 1.044 |
| [11C]ABP (N=41) | |||||||||
| MRTM2 (average) | 0.856 | 0.747 | 1.92 | 8.156 | 0.088 | — | — | ||
| MRTM2 (median) | 0.852 | 0.726 | 1.74 | 8.037 | 0.085 | — | — | ||
| LEGA RR | — | — | — | — | — | 0.909 | 0.885 | 0.00 | 0.772 |
| [11C]WAY (N=287) | |||||||||
| MRTM2 (median) | 0.608 | 0.831 | 0.32 | 26.374 | 0.036 | — | — | ||
CV, coefficient of variation; FRTM, full reference tissue model; LEGA, likelihood estimation in graphical analysis; MRTM, multilinear reference tissue model; PD, percentage difference; ROI, region of interest; RR, reference region; SRTM, simplified reference tissue model.
ROI analysis: correlation, weighted regression analysis, percentage of outliers, PD, and CV results organized by radioligand. Voxel analysis: correlation, weighted regression analysis, percentage of outliers, and CV results organized by radioligand. Only the RRAs and radioligands matching the requirements laid out in Materials and methods are included.