Figure 1.

The effect of dietary restriction (DR) on stroke death of stroke-prone spontaneously hypertensive rats (SP-SHRs). Three-month-old male SP-SHRs were randomly divided into two groups and fed standard feed (Control, ad libitum (AL), n=33) or placed on dietary restricted feed (DR, n=33). (A) The amount of food in DR rats was adjusted every week according to the food intake in control rats. Body weight was recorded in the two groups every 2 weeks. Data are expressed as mean±s.d. *P<0.05, **P<0.01. Student's t-test. (B) The difference in appearance between control and DR groups. (C) The brains of dead SP-SHRs with neurologic sings showed hemorrhages (top-left), ischemia or edema (top-right). Microscopic images of brain section of SHR-SPs suffering from stroke. Hemorrhages (black arrow) or edema (red arrow) were observed in the brain. (D) Kaplan–Meier analysis was used to estimate survival probabilities in the two groups.