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. 2013 Feb 27;33(6):834–845. doi: 10.1038/jcbfm.2013.30

Figure 6.

Figure 6

Post-traumatic redistribution of AQP4 localization. Localization of AQP4 was assessed by high-power confocal microscopy 14 days after moderate TBI. (A) On the contralateral side, AQP4 immunoreactivity is confined to perivascular endfeet (arrowheads) and generally does not co-localize with large glial fibrillary acidic protein (GFAP)-positive astrocytic processes (arrows). Insets depict XZ and YZ projections at planes indicated by white lines. (B) After moderate traumatic brain injury (TBI), a large proportion of AQP4 immunoreactivity has shifted to the membrane of GFAP-positive reactive astrocyte soma and coarse processes (arrows). AQP4 immoreactivity is also evident diffusely surrounding GFAP-positive processes, presumably corresponding to fine astrocytic processes. Insets depict XZ and YZ projections at planes indicated by white lines. Scale bars: 25 μm.