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. 2013 Mar 6;33(6):944–953. doi: 10.1038/jcbfm.2013.35

Figure 6.

Figure 6

Changes in brain water content and hemorrhage volume after the injection of a phosphorylated signal transduction and activator of transcription (pSTAT) inhibitor (NSC74859). (A) After the inhibition of pSTAT3 using NSC74859 in the leptin-injected group (n=5), the brain water content was decreased to the level of the control group (*P<0.05 by Mann–Whitney U test to directly compare between the leptin+intracerebral hemorrhage (ICH) group and the leptin+NSC74859+ICH group). However, the injection of NSC74859 in the control group (n=5) did not induce a change in brain water content compared with the vehicle-only group. (B) The hemorrhage volumes were not different between the groups (n=5 each). (C) Tyrosine kinase receptor of leptin (ObRb) pSTAT3 in cytosol, and translocated pSTAT3 into nucleus initiated transcription of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) genes. After that, COX-2 and iNOS were excessively expressed after ICH in leptin-injected group.