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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: Cell. 2013 Apr 25;153(3):707–720. doi: 10.1016/j.cell.2013.03.030

Figure 4. Module Relevance to LOAD Pathology and Enrichment of Brain eSNPs.

Figure 4

(A) A heat-map of the correlations (∣r∣) between 49 module principal components (PCs) and 25 LOAD-related neuropathology traits. These modules contain at least 100 probes. AT, atrophy; WMAT, white matter atrophy; EL, enlargement. (B) Number of significant module-dependent correlation to LOAD related neuropathology of all differentially connected modules with at least 100 members and showing significant correlation to at least single neuropathology trait (see Extended Experimental Procedures). The total number of traits associated with a module was used to rank-order modules for relevance to LOAD pathology. (C) We tested the enrichment of brain eSNPs in the differentially connected modules of the multi-tissue co-expression network in LOAD as per brain region. Here we present a significant enrichment of brain eSNPs in many of the PFC modules. We used the FET analysis to access the significance of the overlap between each module and cis eSNPs, correcting for the number of modules tested. See also Figure S2 and Table S1.