Table 2.
Summary of remission or response by baseline patient-clinician assessment discrepancy for acute phase ITT population.
| Patient Category at Acute Phase Baseline | Remission |
Response |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HAM-D17 |
CGI-S |
IDS-SR |
HAM-D17 |
CGI-C |
IDS-SR |
|||||||
| Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
|
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
| Underrating | 75 (46) | 89 (54) | 97 (59) | 67 (41) | 74 (45) | 90 (55) | 121 (74) | 43 (26) | 125 (76) | 39 (24) | 89 (54) | 75 (46) |
| Concordant | 361 (51) | 353 (49) | 425 (60) | 289 (40) | 294 (41) | 419 (59) | 528 (74) | 186 (26) | 545 (76) | 169 (24) | 418 (59) | 295 (41) |
| Overrating | 67 (45) | 81 (55) | 81 (55) | 67 (45) | 51 (35) | 97 (66) | 102 (69) | 46 (31) | 108 (73) | 40 (27) | 85 (57) | 63 (42) |
CGI-C = Clinical Global Impressions–Change; CGI-S = Clinical Global Impressions–Severity; HAM-D17 = 17-item Hamilton Rating Scale for Depression; IDS-SR = Inventory of Depressive Symptomatology–Self-Report; ITT = intent to treat.
Remission is defined as: HAM-D17 ≤ 7; CGI-S ≤2; IDS-SR ≤ 14.
Response is defined as: HAM-D17 decrease ≥ 50% from acute phase baseline; CGI-C ≤ 2; IDS-SR decrease ≥ 50% or more from acute phase baseline.
All Mantel-Haenszel chi-square test P-values > .05 (not significant).