Table 4.
Remission or response in continuation phase by Week 10 clinician-patient assessment discrepancy.
| Visit | Patient Category at Week 10 | Remission |
Response |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HAM-D17 | CGI-S | IDS-SR | HAM-D17 | CGI-C | IDS-SR | ||||||||
| Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
Yes |
No |
||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||
| Month 6 | Underrating | 34 (74) | 12 (26) | 38 (83) | 8 (17) | 39 (85) | 7‡ (15) | 40 (87) | 6* (13) | 38 (83) | 8 (17) | 39 (85) | 7‡ (15) |
| Concordant | 275 (83) | 56 (17) | 299 (91) | 31 (9) | 234 (71) | 97 (29) | 314 (95) | 17 (5) | 299 (91) | 31 (9) | 277 (84) | 54 (16) | |
| Overrating | 37 (64) | 21 (36) | 44 (76) | 14 (24) | 20 (34) | 38 (66) | 57 (98) | 1 (2) | 44 (76) | 14 (24) | 32 (55) | 26 (45) | |
| Final Visit | Underrating | 44 (60) | 30 (40) | 55 (74) | 19 (26) | 56 (76) | 18‡ (24) | 58 (78) | 16 (22) | 55 (74) | 19 (26) | 57 (77) | 17‡ (23) |
| Concordant | 379 (76) | 123 (24) | 415 (83) | 87 (17) | 321 (64) | 180 (36) | 451 (90) | 51 (10) | 415 (83) | 87 (17) | 389 (78) | 112 (22) | |
| Overrating | 60 (59) | 42 (41) | 69 (68) | 33 (32) | 32 (32) | 69 (68) | 88 (86) | 14 (14) | 69 (68) | 33 (32) | 50 (50) | 51 (50) | |
CGI-S = Clinical Global Impressions–Severity; HAM-D17= 17-item Hamilton Rating Scale for Depression; IDS-SR = Inventory of Depressive Symptomatology – Self-Report.
Remission is defined as: HAM-D17≤ 7; CGI-S ≤2; IDS-SR ≤ 14.
Response is defined as: HAM-D17 decrease >50% from acute phase baseline; CGI-C ≤2; IDS-SR decrease ≥50% or more from acute phase baseline.
*
P≤ 0.05 from 3-way Mantel-Haenszel chi-square test.
†
P≤ 0.01 from 3-way Mantel-Haenszel chi-square test.
‡
P≤ 0.001 from 3-way Mantel-Haenszel chi-square test.