Fig. 10.

Antioxidant and antiapoptotic effects of CORM-A1 against endothelial injury caused iGluR agonists. Confluent quiescent CMVEC were incubated with NMDA, AMPA, or kainic acid (0.1 mM) in the absence or presence of 50 μM CORM-A1 at 37°C for 1 h (A) or 3 h (B). A: ROS production was detected by accumulation of Ox-DHE fluorescent products and expressed as %baseline values. B: apoptosis was detected by DNA fragmentation and expressed as %baseline values. Data represent the average of 3 experiments. Values are means ± SE. *P < 0.05, compared with basal values. †P < 0.05, compared with the corresponding values in the absence of CORM-A1.