Fig. 7.

Contributions of iGluRs to glutamate-induced apoptosis in CMVEC. Confluent quiescent CMVEC were incubated with 2 mM glutamate alone (Ctr) or supplemented with antagonists of NMDARs (D-AP5, 4C3HPG, 0. 1 mM) and non-NMDARs (DNQX, NBQX, 0.1 mM) for 3 h at 37°C. Apoptosis was detected by DNA fragmentation (A) or by cell detachment from the substrate (B) and expressed as %baseline values. Data represent the average of 4 experiments. Values are means ± SE. *P < 0.05, compared with the basal values. †P < 0.05, compared with glutamate alone.