Table 1.
Level of gene up-regulation from comparative microarray analysis in A. gambiae from Bioko compared with the susceptible Ngusso strain
| Transcript ID | Description (Blast2GO annotation) | Fold change |
||
| Ngusso vs. nonexposed | Ngusso vs. deltamethrin survivors | Ngusso vs. bendiocarb survivors | ||
| Detoxification genes | ||||
| AGAP012296-RA | CYP9J5: cytochrome P450 monooxygenase | 17 | 7.61 | |
| AGAP002113-RB | Cytochrome b5 | 4.00 | ||
| AGAP005992-RA | CYP302A1: cytochrome P450 monooxygenase | 3.26 | 3.59 | 3.25 |
| AGAP002863-RA | COEA6O: carboxylesterase | 2.59 | ||
| AGAP000284-RA | Cytochrome P450 | 2.39 | 2.21 | |
| AGAP002113-RC | Cytochrome b5 | 2.33 | ||
| AGAP004380-RA | Glutathione transferase GSTD12 | 2.30 | 2.52 | 2.35 |
| AGAP002429-RA | CYP315A1: cytochrome P450 monooxygenase | 2.27 | 2.22 | |
| AGAP005371-RA | COEBE2C: carboxylesterase | 2.06 | ||
| AGAP002416-RA | CYP4K2: cytochrome P450 monooxygenase | 2.01 | ||
| AGAP002417-RA | CYP4AR1: cytochrome P450 monooxygenase | 2.68 | ||
| AGAP002419-RA | CYP4D22: cytochrome P450 monooxygenase | 3.48 | 3.80 | |
| AGAP004164-RC | GSTD1_4: glutathione S-transferase | 2.23 | ||
| AGAP004383 RA | GSTD10: glutathione S-transferase | 2.97 | ||
| AGAP007480-RA | CYP6AH1: cytochrome P450 monooxygenase | 4.59 | 5.85 | |
| AGAP008209-RA | CYP6M1: cytochrome P450 monooxygenase | 2.54 | ||
| AGAP012295-RA | CYP9L1: cytochrome P450 monooxygenase | 10.82 | ||
| Cuticular genes | ||||
| AGAP006497-RA | CPR134: cuticle protein | 3.71 | ||
| AGAP003385-RA | CPR123: cuticle protein | 3.20 | ||
| AGAP003379-RA | CPR 117: cuticle protein | 3.08 | ||
| AGAP012795-RA | Cuticle protein putative | 2.10 | ||
| AGAP010906-RA | CPFL5: cuticular protein 5 from CPFL family | 4.28 | ||
| AGAP010908-RA | CPFL7: cuticular protein 7 from CPFL family | 2.80 | ||
| Oxidative stress | ||||
| AGAP006226-RA | Aldehyde oxidase | 46.13 | 41.74 | 35.40 |
| AGAP011054-RA | TPX2: thioredoxin-dependent peroxidase | 21.99 | 21.63 | 24.37 |
| ABC transporters | ||||
| AGAP011518-RA | ATP-binding cassette subfamily a member = ABCA1 | 4.37 | 3.51 | |
| AGAP010416-RA | ABC transporter | 2.01 | ||
| AGAP007504-RA | ATP-binding cassette subfamily a member | 2.68 | ||