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. 2013 May 20;110(23):9469–9474. doi: 10.1073/pnas.1300532110

Fig. 6.

Fig. 6.

IKKVI promoted the repair of calvarial bone defect mediated by MSCs in vivo. (A) IKKVI promoted the repair of calvarial bone defects as determined by μCT. Rat MSCs were loaded on apatite-coated PLGA scaffolds with or without IKKVI. The scaffolds were placed on the calvarial defects. 10 wk post operation, the calvarias were harvested and the defect repairs were examined by μCT. Dotted circle, defect area. (B) IKKVI promoted the repair of calvarial bone defect as determined by H&E staining and immunohistochemistry. B, new bone; S, apatite-coated PLGA scaffold. (Scale bar, 100 μm.) (C) IKKVI enhanced BMD as determined by μCT. (D) Qualitative measurement of bone formation by μCT. **P < 0.01.