Fig. 4.

Induction of tau inclusions following the intracerebral injection of induced mouse brain homogenates, as detected by Gallyas-Braak silver impregnation. (A) Neuropil threads and coiled bodies in the alveus and (B) neurofibrillary tangle in the subiculum of an ALZ17 mouse 12 mo after the injection of brain homogenate from an ALZ17 mouse that had 18 mo previously been injected with brain homogenate from a mouse transgenic for human mutant P301S tau. (C and D) ALZ17 mouse 12 mo after the injection of brain homogenate from a C57BL/6 mouse that had 18 mo previously been injected with TD brain homogenate. (Scale bars, 50 µm.) Sections were counterstained with hematoxylin.