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. 2013 May 20;110(23):E2116–E2125. doi: 10.1073/pnas.1307185110

Fig. 2.

Fig. 2.

Suppression of systemic autoimmunity/inflammation in Scurfy mice by IL-2 deficiency and transgenic CTLA-4 expression. (A) Survival of Scurfy, IL2KO Scurfy, C4Tg Scurfy, and IL2KO-C4Tg Scurfy mice. (B) The weight (mean ± SD) of spleens at 2–3 wk of age (n = 3–5 each). (C) Expression of CD25 and intracellular Ki-67 by lymph node CD4+ T cells. (D) Expression of CD69 by lymph node CD4+ and CD8+ T cells. (E) Intracellular staining of IL-4 and IFN-γ in indicated lymph node CD4+ T cells. (F) Proportions of lymph node CD4+ T cells producing indicated cytokines (n = 3–5 each). Numbers in C–E indicate the percentages in gated areas. Representative staining of three to five mice in C–E.