Fig. 5.

Correlation plots showing significant PCCs between each parameter that was varied in the population and each biomarker. Coefficient values are represented using the included color bar. For each parameter–biomarker pair, the effects on the biomarker attributable to the unselected parameters are removed as part of the partial correlation method. PCCs are shown for each frequency used in our simulations (2, 1, and 0.2 Hz). Parameter–biomarker pairs with higher coefficient values displayed stronger partial correlation with each other, whereas pairs with a coefficient of 0 did not show statistically significant partial correlation (P < 10⁻⁵). and , positive and negative correlation, respectively.