. Author manuscript; available in PMC: 2013 Jun 10.

Published in final edited form as: Trends Cell Biol. 2005 Aug;15(8):404–413. doi: 10.1016/j.tcb.2005.06.003

Table 1.

Conserved components of the spindle midzone/midbody and phragmoplast^a

C. elegans	D. melanogaster	Mammals	S. pombe	S. cerevisiae	Plants	Refs
SPD-1	Fasceto/FEO	PRC1	Ase1p	Ase1p	MAP-65	[28,29,31–34,37]
CYK-4	RacGAP50C/Tumbleweed	MgcRacGAP	Rga7p	Rgd1p	At4g24580	[1,93]
ZEN-4	Pavarotti/PAV	MKLP1/CHO1, RabK6/MKLP2	– – –	– – –	At1g20060 (AtT20H2.17)	[1,7,95]
AIR-2	DmAuroraB	AuroraB/AIM-1	Ark1p	Ipl1p	At-Aurora 1, -2	[7,96,97]
ICP-1	DmINCENP	INCENP	Pic1p	Sli15p	– – –	[1,96]
BIR-1	Deterin	Survivin	Bir1p/Cut17p	Bir1p	– – –	[1,96]
CSC-1	DmBorealin	Borealin/CDCa8	– – –	– – –	– – –	[1,96]
CDC-14	CG7134	Cdc14a	Cdc14p, Clp1p/Flp1p	Cdc14p	– – –	[98–100]
KLP-12, KLP-19	KLP3A	KIF4	– – –	– – –	FRA1/At5g47820, At3g50170, At5g60930	[7,49,101,102]
BMK-1	KLP61F	BimC	Cut7p	Kip1p, Cin8p	TKRP125, DcKRP120–2	[53,103–107]
PLK-1, -2, -3	Polo	PLK1–4	Plo1p	Cdc5p	At4g24400	[108]
TAC-1	d-tacc	TACC1	– – –	– – –	– – –	[109–111]
ZYG-9	Msps	ch-TOG/XMAP215 homolog	Dis1p, Alp14p	Stu2p	MOR1/GEM1	[7,46,112,113]
KLP-3, -15, -16, -17	*Ncd*	*KIFC1/CHO2*, KIFC2, KIFC3	Pkl1p, Klp2p	Kar3p	AtK1/AtKatA, AtK2/AtKatB, AtK3/AtKAtC, AtK4/AtKatD, AtK5, AtKCBP	[7,55,57,114]
EBP-1, VW02B12L.3	DmEB1	EB1	Mal3p	Bim1p	AtEB1	[7,115–118]
Y48G8AL.1	CG9135	TD-60	Pim1p	– – –	At1g19880	[119,120]
C33D9.8	dCLP-190	CLIP-170/Restin	Tip1p	Bik1p	MCLIP-170	[7,115,121]
DYN-1	Shibire	Dynamin II	Dnm1p	Dnm1p	DRP2A^b, AtDRP1/Phragmoplastin, ADL1A, ADL1E	[7,76,122,123]
CDK-1	Cdc-2	p34cdc2/CDK1	Cdc2p	Cdc28p	CDC2	[7,124–126]
SYN-4^*	Syntaxin 5^*	Syntaxin 2^*	– – –	– – –	KNOLLE/AtSYP111^*^c	[66–69]
CYK-1	Diaphanous/DIA1	Formin/mDia	Bni1p	Cdc12p	AtFH5	[25,127–130]

Proteins in bold have been shown to localize to and/or were isolated from the spindle midzone/midbody or phragmoplast. Proteins in italics have been localized to other structures but not shown to localize to the spindle midzone/midbody or phragmoplast. Proteins underlined have not been localized. Dashed lines indicate the lack of a clear ortholog.

These proteins might not be homologs, but syntaxins are involved in cytokinesis in many organisms.

DRP2A is related to conventional animal dynamins, which are involved in clathrin-coated vesicle formation and membrane fission during endocytosis. Some members of the DRP1 family appear to constrict cell-plate membranous tubules without leading to membrane scission.

KNOLLE, a cytokinesis-specific SNARE, is also a plant-specific member of the Arabidopsis SYP1 family.