Figure 8. 6BIO protects neuronal cultures from the HIV-1 Tat protein.
Rat mixed hippocampal cultures were preincubated with various concentrations of (A) 6BIO (0.05-10 μM) or (B) 6BIOder (0.05-10 μM) for 1 hour at 37°C prior to an 18 hour exposure to 500 nM Tat1-72. After 18 hours, cell survival was measured by MTT assay. Statistical significance was determined by ANOVA, followed by Newman-Keuls post hoc pair-wise comparisons.