Table 2.
Motor and cognitive systems implicated by cerebellar structural abnormalities in autistic disorder
| Functions affected in AD | Cerebellar lobule |
Lateralization in cerebellum | Cerebellar dysfunction in AD? |
||
|---|---|---|---|---|---|
| Motor | Skeletomotor | Vestibular, gross and fine motor control |
I-V,VIII | Ipsi dominant | Y |
| Oculomotor | Saccade amplitude; pursuit gain | Vermis VI-VII | Contra dominant (saccades) Ipsi dominant (smooth pursuit) |
Y | |
| Cognitive | EF/Attention | Response inhibition, planning, set shifting |
VI, VIIB; Crus I |
Left dominant for spatial attention | N |
| Memory | Working memory, procedural memory |
VI, VIIB, VIIIA; Crus I |
None | N | |
| Language | Phonological processing, articulation, fluency, auditory comprehension |
VI-VII; Crus I/II |
Right dominant (for righthanders) | Y |
EF executive function, attn attention; Ipsi ipsilateral, Contra contralateral, Y yes, N no