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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Future Microbiol. 2013 Feb;8(2):257–269. doi: 10.2217/fmb.12.134

Figure 2. pH (low) insertion peptide targets infected but not uninfected mouse lungs.

Figure 2

Representative whole-lung images from three independent experiments (n ≥4). pHLIP was administered to influenza A/Puerto Rico/8/34-infected mice on day 10 postinfection. (A–D) DAPI (blue) and pHLIP (red). (B & D) At 12 dpi, pHLIP can only be detected in infected lungs.

(A & C) Control lungs from uninfected and infected mice. (E–H) H&E staining of the same samples. Darkened areas indicate regions of immune cell infiltration and inflammation.

dpi: Days postinfection; H&E: Hematoxylin and eosin; pHLIP: pH (low) insertion peptide.