Table 2.

Minor allele frequencies (MAF) and odds ratios (OR) from association tests of ET and 20 SNPs throughout the SNCA locus.

		Mayo 135 cases 423 controls		Canada 201 cases 313 controls		Emory 118 cases 267 controls		Columbia 193 cases 282 controls		Combined samples
Chr4 (bp)†	SNP	MAF: cases controls	OR (95% CI)	MAF: cases controls	OR (95% CI)	MAF: cases controls	OR (95% CI)	MAF: cases controls	OR (95% CI)	Combined OR (95% CI)	P- value*
90637010	rs356218	0.311	0.96	0.308	0.91	0.326	0.99	0.396	1.29	1.04	0.621
		0.319	(0.72-1.3)	0.329	(0.69-1.2)	0.315	(0.70-1.4)	0.328	(0.99-1.7)	(0.90-1.2)
90653134	rs17180453	0.074	0.93	0.075	0.87	0.055	0.66	0.093	1.02	0.89	0.363
		0.079	(0.56-1.6)	0.085	(0.55-1.4)	0.071	(0.34-1.3)	0.087	(0.65-1.6)	(0.69-1.1)
90657491	rs3775423	0.111	1.56	0.075	0.89	-	-	-	-	1.08	0.35
		0.073	(0.99-2.5)	0.083	(0.56-1.4)	-	-	-	-	(0.92-1.3)
90678541	rs2736990Φ	0.467	1.02	0.463	1.06	0.479	1.02	-	-	1.03	0.654
		0.462	(0.78-1.3)	0.447	(0.83-1.4)	0.507	(0.75-1.4)	-	-	(0.90-1.2)
90678798	rs2572324	0.289	1.05	0.286	0.98	0.275	0.93	0.298	1.09	1.02	0.808
		0.279	(0.78-1.4)	0.289	(0.74-1.3)	0.26	(0.65-1.3)	0.27	(0.82-1.4)	(0.88-1.2)
90687507	rs3796661	0.022	0.83	0.02	0.63	0.03	1.37	0.036	0.69	0.79	0.241
		0.027	(0.35-2.0)	0.032	(0.28-1.4)	0.028	(0.55-3.5)	0.055	(0.36-1.3)	(0.53-1.2)
90707947	rs2737033	0.278	1.14	0.251	0.87	0.28	0.99	0.256	1.03	1	0.998
		0.252	(0.84-1.5)	0.278	(0.65-1.2)	0.258	(0.70-1.4)	0.241	(0.77-1.4)	(0.86-1.2)
90709741	rs3775439Φ	0.144	1	-	-	0.148	1.14	0.148	0.9	0.99	0.926
		0.144	(0.67-1.5)	-	-	0.182	(0.73-1.8)	0.186	(0.63-1.3)	(0.79-1.2)
90712629	rs10014396	0.126	1.01	-	-	0.114	0.89	0.098	0.77	0.88	0.328
		0.125	(0.66-1.5)	-	-	0.152	(0.55-1.4)	0.138	(0.50-1.2)	(0.68-1.1)
90716177	rs9995651	0.067	1.76	0.037	0.97	0.047	0.82	0.021	0.58	1.01	0.966
		0.04	(0.96-3.2)	0.038	(0.50-1.9)	0.075	(0.40-1.7)	0.048	(0.25-1.3)	(0.71-1.4)
90721637	rs2583959	0.278	1.19	0.241	0.83	0.271	0.98	0.251	1.05	1	0.993
		0.243	(0.88-1.6)	0.276	(0.62-1.1)	0.243	(0.69-1.4)	0.23	(0.78-1.4)	(0.86-1.2)
90745707	rs2737012	0.281	1.23	0.241	0.84	0.271	0.99	0.251	1.05	1.01	0.884
		0.241	(0.90-1.7)	0.275	(0.62-1.1)	0.242	(0.70-1.4)	0.23	(0.78-1.4)	(0.87-1.2)
90757309	rs1372519‡	0.193	0.81	0.228	1.12	0.195	0.83	0.263	1.25	1.01	0.926
		0.23	(0.58-1.1)	0.208	(0.83-1.5)	0.23	(0.56-1.2)	0.223	(0.92-1.7)	(0.86-1.2)
90757394	rs3756063‡	0.474	1	0.468	0.93	0.466	0.88	0.513	1.2	1.01	0.937
		0.474	(0.76-1.3)	0.484	(0.72-1.2)	0.472	(0.64-1.2)	0.456	(0.92-1.5)	(0.88-1.2)
90757505	rs1372520‡	0.193	0.81	0.226	1.11	0.195	0.85	0.263	1.26	1.01	0.871
		0.23	(0.58-1.1)	0.208	(0.82-1.5)	0.226	(0.57-1.2)	0.22	(0.93-1.7)	(0.86-1.2)
90757735	rs2619361	0.281	1.21	0.241	0.83	0.271	0.99	0.251	1.04	1	0.953
		0.243	(0.89-1.7)	0.276	(0.62-1.1)	0.242	(0.70-1.4)	0.232	(0.77-1.4)	(0.86-1.2)
90757845	rs2619362	0.281	1.21	0.241	0.85	0.275	1.01	0.251	1.03	1.01	0.866
		0.243	(0.89-1.7)	0.271	(0.63-1.1)	0.242	(0.72-1.4)	0.234	(0.77-1.4)	(0.87-1.2)
90758389	rs2301135	0.477	0.96	0.47	0.94	0.466	0.86	0.518	1.21	1	0.957
		0.488	(0.73-1.3)	0.485	(0.72-1.2)	0.479	(0.63-1.2)	0.457	(0.94-1.6)	(0.87-1.1)
90759047	rs2619363	0.278	1.19	0.239	0.82	0.271	1.01	0.249	1.02	1	0.979
		0.243	(0.88-1.6)	0.275	(0.62-1.1)	0.238	(0.71-1.4)	0.232	(0.76-1.4)	(0.85-1.2)
90760828	rs2583988	0.272	1.17	0.241	0.85	0.276	1.03	0.249	0.97	0.99	0.888
		0.242	(0.86-1.6)	0.272	(0.63-1.1)	0.241	(0.72-1.5)	0.245	(0.72-1.3)	(0.85-1.2)

Entries of “-” indicate that a SNP was excluded from analysis for a particular cohort due to HWE failure in either ET samples or controls. Chr4 (bp) = Chromosome 4 base pair.

^*P-value given for combined series analysis

^†Chromosomal positions based on the February 2009 (GRCH37/hg19) genome assembly

^‡SNPs that overlap with Pigullo et al36

^ΦSNPs that are present on the Illumina HumanHap300 array16