Table I.

Biologic effect of selected products of oxidized phospholipids

OxPLs	Potential Receptors	Bioactivities
		Proinflammatory Effects	Anti-Inflammatory Effects
POVPC	PPARγ, PAF receptor CD36	Stimulates ECs to bind monocytes Induces activation of IL-8 gene and α5β1 integrin. Induces MCP-1 expression9 Increases deposition of CS-1 on cell surface3	Inhibits LPS-induced E-selectin expression and neutrophil adhesion3
PGPC	PPARα, VEGFR2	Induces both monocyte and neutrophil binding to ECs11 Induces VCAM-1 and E-selectin expression3
PEIPC	EP2, TLR4, PPARα	Induction of monocyte/EC adhesion11 Regulation of MCP-1 and IL-8 expression Activation of TF and PPARα9	Enhances EC barrier function10
PECPC	PPARα	Increases MCP-1 and IL-1 synthesis9	Enhances EC barrier function10
Lyso-PC	GPR4, G2A	Upregulates VCAM-1, ICAM-1, and P-selectin expression77
KOdiAPC	CD36		Inhibits LPS induction of E-selectin and IL-867