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. 2013 May 25;2013:393460. doi: 10.1155/2013/393460

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Copyright © 2013 Yin Shou et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A hypothetical diagram illustrating the EA action that is mediated by CB1 in the adjuvant arthritis (AA) rat. The intra-articular injection of Complete Freund's adjuvant (CFA) promotes the expression of CB1, D1, and D2. EA stimulation at specific acupoints results in a much higher expression of these three receptors, but the CB1 receptor antagonist AM251 can reverse these antinociceptive effects. Compared to the action of WIN55212-2, EA mainly produces its effects by upregulating the cross-modulation of dopamine receptors and CB1 in the corpus striatum, while WIN55212-2, which is a potent CB1 receptor agonist, exerts its function on the relationship between CB1 and D1 for pain relief.