Table 2.

Antileishmanial activity, cytotoxicity, and selective indexes of tested compounds for HepG2 cells and murine macrophages.

Compound	Formula	IC50 a	HepG2		Macrophages
			MLD50 b	SIc	MLD50 b	SIc
(1)	(Lp)(Ph3Bi)O0.5	29.05 ± 18.45	58.38 ± 8.47	2.01	32.4 ± 8.20	1.11
(2)	(Lp)(Ph3Sb)OH	18.27 ± 5.58	325.22 ± 89.40	17.81	130.65 ± 40.52	7.15
(3)	(Lp)(Ph3Sn)	0.17 ± 0.03	12.01 ± 0.17	70.65	1.6 ± 0.57	9.41
(4)	Ph3BiCl2	5.40 ± 0.16	183.75 ± 4.77	34.03	25.15 ± 0.49	4.67
(5)	Ph3SbCl2	11.61 ± 7.85	157.46 ± 37.13	13.56	30.75 ± 6.01	2.65
(6)	Ph3SnCl2	0.10 ± 0.11	12.04 ± 8.42	120.35	0.73 ± 0.13	7.30
(7)	Lpd	15.48 ± 5.23	201.77 ± 5.32	13.03	184.65 ± 6.58	11.92
Amphotericin B		0.73 ± 0.60	644.59 ± 126.57	883.00	179.95 ± 8.84	246.51

^aIC₅₀: the inhibitory concentration that killed 50% of the L. amazonensis in μg/mL.

^bMLD₅₀: the minimum lethal dose that killed 50% of the cells in μg/mL.

^cSI: selective index, calculated based on the MLD₅₀/IC₅₀ ratios.

^dLp: Lapachol.