Figure 4.

Histological appearance of a selected case analyzed. A) Low power slide scan demonstrating the heterogeneity of the disease. Note the occurrence of malignant transformation in different parts of the gland, areas of high grade disease (Gleason >8) and small areas of low grade cancer are both occurring in the peripheral zone. B) High magnification of the high grade area. Note the complete loss of normal gland pattern with solid tumor cell clustering. C) Low Gleason score areas also in the peripheral zone. The micrographs highlight the need for cell enrichment for the analysis of prostate cancer samples.