Table 2.
MDS samples: Demographics, clinical characteristics, absolute CFUs, and fold-augmentation in 3% O2
| Absolute CFU/104 MNC | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GM | E | Fold change* | |||||||||||||
| Sample | Patient | Sex | Age (y) | Diagnosis | WBC (103/µL) |
Hb (g/dL) |
Plt (103/µL) |
Blasts (%) | IPSS | 18.6% | 3% | 18.6% | 3% | GM | E |
| 202 | R0283 | M | 63 | RAEB-2 | 1.7 | 9.1 | 22 | 19 | INT-2 | 37.3 | >150 | <2 | <2 | 14.19† | NE |
| 218‡ | R0296 | F | 59 | RAEB-2 | 7.1 | 9.4 | 45 | 16 | High | 21.8 | 29.2 | <2 | <2 | 1.34 | NE |
| 234§ | R0306 | M | 60 | RCMD | 2.7 | 7.1 | 46 | 2 | INT-1 | 3.5 | 59.3 | <2 | 2.3 | 16.79 | NE |
| 246‡ | R0296 | F | 59 | RAEB-2 | 18.4 | 9.2 | 5 | 14 | High | 45.8 | 60.2 | <2 | <2 | 1.31 | NE |
| 253§ | R0306 | M | 60 | RCMD | 2.3 | 9.6 | 34 | 2 | INT-1 | 7.2 | 65.0 | <2 | <2 | 9.03 | NE |
| 260 | R0321 | M | 78 | RCMD | 1.9 | 6.9 | 189 | <5 | INT-1 | 7.0 | 17.7 | 16.4 | 25.8 | 2.34 | 1.45 |
| 298 | R0350 | M | 63 | RCMD | 8.8 | 13.9 | 52 | 4 | Low | 21.7 | 52.7 | 6.7 | 18.0 | 2.66 | 1.75 |
| 306 | R0356 | M | 77 | RCMD | 3.7 | 8.9 | 185 | 1 | Low | 21.3 | 45.3 | <2 | 29.3 | 2.13 | > 14.67 |
| 308 | R0342 | M | 73 | RAEB-2 | 1.9 | 11.1 | 56 | 18 | INT-2 | 2.5 | 3.8 | 5.3 | 5.7 | 1.50 | 1.09 |
| 313 | R0361 | M | 65 | RAEB-1 | 12.7 | 13 | 34 | 8 | INT-1 | 10.2 | 16.5 | 27.0 | 21.0 | 1.63 | 0.78 |
| 470 | R0398 | M | 70 | RAEB-1 | 2.3 | 10.8 | 7 | 5 | INT-2 | 13.5 | 350 | 2.3 | 2.3 | 25.89 | 1.00 |
| 496 | R0496 | M | 45 | RA | 2.8 | 11.8 | 90 | 0 | INT-2 | 7.5 | 9.5 | 7.1 | 10.1 | 1.26 | 1.42 |
| 584 | R0556 | M | 62 | RCMD | 8.1 | 9.4 | 93 | 3 | Low | 7.9 | 75.8 | <2 | 16.7 | 9.60 | > 8.33 |
CFU = colony-forming units; E = erythroid colonies; F = female; GM = combined myeloid (granulocyte, monocyte, and granulocyte-monocyte) colonies; Hb = hemoglobin; INT = intermediate; IPSS = International Prognostic System Score; MNC = mononuclear cells; NE = not evaluable; Plt = platelet count; R XXXX5 patient registry number XXXX; M = male; RAEB = refractory anemia with excess blasts; RA = refractory anemia; RCMD = refractory cytopenia with multilineage dysplasia; WBC = white blood cell count.
Italics indicates CFU fold-changes greater than that observed in normal controls but less than eightfold, while bold indicates greater than eightfold CFU augmentation.
Fold-change based on CD34+ cell results.
Sample 246 was obtained 50 days after sample 218, both from patient R0296.
Sample 253 was obtained 50 days after sample 234, both from patient R0306.