Table 1.
Association between EZH2 Expression and Patient Characteristics
| EZH2 Expression | ||||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | No. of Patients | Weak (0–1) | Moderate (2) | Strong (3) | P | |||
| No. | % | No. | % | No. | % | |||
| All patients | 76 | 16 | 21 | 26 | 34 | 34 | 45 | |
| Age, years | ||||||||
| Mean ± SD | 55.1 ± 13.6 | 52.4 ± 11.1 | 52.7 ± 13.6 | 58.1 ± 14.3 | .24 | |||
| Median | 53.5 | 53.5 | 51.5 | 59.0 | ||||
| Minimum, maximum | 25.0, 82.0 | 28.0, 76.0 | 25.0, 80.0 | 28.0, 82.0 | ||||
| Age group | ||||||||
| <60 years | 47 | 11 | 24 | 18 | 38 | 18 | 38 | .40 |
| ≥60 years | 29 | 5 | 17 | 8 | 28 | 16 | 55 | |
| Sex | ||||||||
| Female | 34 | 5 | 15 | 13 | 38 | 16 | 47 | .48 |
| Male | 42 | 11 | 26 | 13 | 31 | 18 | 43 | |
| Histology | ||||||||
| Dysplasia | 57 | 6 | 11 | 21 | 37 | 30 | 53 | <.001 |
| Other† | 19 | 10 | 53 | 5 | 26 | 4 | 21 | |
| Anatomic Site | ||||||||
| Low risk areas* | 31 | 11 | 35 | 9 | 29 | 11 | 35 | .04 |
| High risk areas* | 45 | 5 | 11 | 17 | 38 | 25 | 51 | |
| Smoking Status | ||||||||
| Yes | 14 | 4 | 28 | 5 | 36 | 5 | 36 | .45 |
| No | 51 | 8 | 16 | 17 | 33 | 26 | 51 | |
| Unknown | 11 | 4 | 36 | 4 | 36 | 3 | 28 | |
| Alcohol ConsumptionStatus | ||||||||
| Yes | 17 | 6 | 35 | 6 | 35 | 5 | 30 | .09 |
| No | 48 | 6 | 13 | 16 | 33 | 26 | 54 | |
| Unknown | 11 | 4 | 36 | 4 | 36 | 3 | 28 | |
Abbreviations: SD, standard deviation; P, p-value of the Kruskal-Wallis test for age as a numeric variable and that of Fisher’s Exact test for age group and other variables.
†
Other: Non dysplastic OL lesions ( Hyperkeratosis, Acanthosis, and Hyperplasia).
*
Low risk areas: buccal mucosa, labial mucosa, gingiva, and palate. High risk areas: floor of mouth, lateral and ventral tongue.