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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Bioconjug Chem. 2013 Apr 2;24(4):658–668. doi: 10.1021/bc300632w

Figure 5.

Figure 5

Penetration of Rhodamine-labeled CHA-ETO (A) and CHA-SAL (B) in MCF-7 multicellular cancer spheroids (MCS) detected by confocal microscopy (12 h, 37°C). White arrows show nanogel penetration (left: contrast image; right: fluorescent image; side length: 500 μm). (C) Schematic view of nanogel penetration into MCS and accumulation in adjacent cells.