Figure 5.
Penetration of Rhodamine-labeled CHA-ETO (A) and CHA-SAL (B) in MCF-7 multicellular cancer spheroids (MCS) detected by confocal microscopy (12 h, 37°C). White arrows show nanogel penetration (left: contrast image; right: fluorescent image; side length: 500 μm). (C) Schematic view of nanogel penetration into MCS and accumulation in adjacent cells.
