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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Apr 11;23(11):3248–3252. doi: 10.1016/j.bmcl.2013.03.113

Table 1.

SAR of the 3-position of pyrazolo[1,5-a]pyrimidine scaffold (7a-m).

graphic file with name nihms-466834-t0004.jpg

Compd R1 BMP4 Cell IC50 (nM)14,15
7a graphic file with name nihms-466834-t0005.jpg Inactive
7b graphic file with name nihms-466834-t0006.jpg Inactive
7c graphic file with name nihms-466834-t0007.jpg Inactive
7d graphic file with name nihms-466834-t0008.jpg 94.1
7e graphic file with name nihms-466834-t0009.jpg Inactive
7f graphic file with name nihms-466834-t0010.jpg Inactive
7g graphic file with name nihms-466834-t0011.jpg 152
7h graphic file with name nihms-466834-t0012.jpg 6,732
7i graphic file with name nihms-466834-t0013.jpg <1
7j graphic file with name nihms-466834-t0014.jpg Inactive
7k H Inactive
7l graphic file with name nihms-466834-t0015.jpg Inactive
7m graphic file with name nihms-466834-t0016.jpg Inactive
7n graphic file with name nihms-466834-t0017.jpg 4,571