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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Apr 11;23(11):3248–3252. doi: 10.1016/j.bmcl.2013.03.113

Table 2.

SAR of the 6- and 3-position of the pyrazolo[1,5-a]pyrimidine scaffold (13a-r).

graphic file with name nihms-466834-t0018.jpg

Compd R2 R3 BMP4 Cell IC50 (nM)14,15
13a graphic file with name nihms-466834-t0019.jpg graphic file with name nihms-466834-t0020.jpg 141
13b graphic file with name nihms-466834-t0021.jpg Inactive
13c graphic file with name nihms-466834-t0022.jpg 529
13d graphic file with name nihms-466834-t0023.jpg <1.0
13e graphic file with name nihms-466834-t0024.jpg inactive
13f graphic file with name nihms-466834-t0025.jpg inactive
13g graphic file with name nihms-466834-t0026.jpg 418

13h graphic file with name nihms-466834-t0027.jpg graphic file with name nihms-466834-t0028.jpg <1.0
13i graphic file with name nihms-466834-t0029.jpg Inactive
13j graphic file with name nihms-466834-t0030.jpg 246
13k Br inactive
13l graphic file with name nihms-466834-t0031.jpg inactive
13m graphic file with name nihms-466834-t0032.jpg 117
13n graphic file with name nihms-466834-t0033.jpg 2,636

13o graphic file with name nihms-466834-t0034.jpg graphic file with name nihms-466834-t0035.jpg Inactive
13p graphic file with name nihms-466834-t0036.jpg Inactive
13q graphic file with name nihms-466834-t0037.jpg 523
13r graphic file with name nihms-466834-t0038.jpg 25.2