Table 4.
In vitro pharmacokinetic properties of ML347
| |||
|---|---|---|---|
| MW | 352.4 | ||
| cLogP | 4.00 | ||
| TPSA | 52.3 | ||
|
| |||
| In vitro PK Parameter | Human | Rat | Mouse |
|
| |||
| CLINT (mL/min/kg) | 516 | 148 | 617 |
| CLHEP (mL/min/kg) | 20.2 | 47.5 | 78.5 |
| PPB (% fu) | 0.9 | 1.4 | 1.4 |
|
| |||
| PBS Solubility | 4 μM | ||
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