Table 1.
Stem cells as prognostic biomarkers in critically ill patients
| Author | Date | Cell Type | Disease | Patients (No.) | Clinical Outcome | p |
|---|---|---|---|---|---|---|
| Mutunga et al | 2001 | Endothelial cells | Sepsis | Septic shock (15) Sepsis (8) ICU control (9) Healthy (11) |
Positive correlation with mortality | .026 |
| Burnham et al | 2005 | Endothelial progenitor cells (colony-forming unit) | ALI/ARDS | ALI (45) ICU control (10) Healthy (7) |
Positive correlation with survival | <.04 |
| Tsaganos et al | 2006 | CD34/CD45 cells | Ventilator-associated pneumonia and sepsis | Sepsis (44) Healthy (8) |
Positive correlation with mortality | .022 |
| Rafat et al | 2007 | Endothelial progenitor cells (FACS) | Sepsis | Sepsis (32) ICU control (15) Healthy (15) |
Positive correlation with survival | <0.0001 |
| Burnham et al | 2009 | Endothelial progenitor cells (colony-forming unit) | Sepsis and ALI/ARDS | ALI (65) Severe sepsis (17) Healthy (5) |
Positive correlation with survival | .06 |
| Cribbs et al | Unpublished data | Endothelial progenitor cells (colony-forming unit) | Sepsis | Sepsis (86) ICU control (37) |
Positive correlation with improved organ dysfunction | <.05 |
ALI, acute lung injury; ARDS, acute respiratory distress syndrome; ICU, intensive care unit; FACS, fluorescence-activated cell sorting.