Figure 27.

Regulation of enhanced gating of the proton channel, as well as NADPH oxidase activity, by PKC-dependent phosphorylation. Top left: proton currents during test pulses to +60 mV applied every 30 s from a holding potential of −60 mV. Examples of currents at an expanded time base are superimposed (right) with lowercase letters identifying the time of the pulse. At the arrows, the PKC activator PMA or the PKC inhibitor GFX (GF109203X) were added. Bottom left: the current at −60 mV at high gain (with pulses blanked) shows inward electron current that reflects NADPH oxidase activity. [From Morgan et al. (335).]