Table 2.
Nomenclature and protein features of selected members of the voltage-gated proton channel (HV1) family
| Proposed Name | Protein GI Number | Protein Identity, % | Organism | Moleular Mass, Da | Length, amino acids |
|---|---|---|---|---|---|
| hHV1 | 34783432 | 100 | Homo sapiens (human) | 31,683 | 273 |
| hHV1s | 374834170 | 92.7 | (Short form; “isoform 2”) | 29,415 | 253 |
| PaHV1 | 297692952 | 96.7 | Pongo abelii (Sumatran orangutan) | 31,756 | 275 |
| MmHV1 | 380790623 | 93.8 | Macaca mulatta (rhesus monkey) | 31,554 | 273 |
| pHV1 | 194042948 | 88.0 | Sus scrofa (wild pig) | 31,863 | 272 |
| AmHV1 | 301754531 | 86.8 | Ailuropoda melanoleuca (giant panda) | 31,749 | 271 |
| cHV1 | 296478571 | 86.2 | Bos taurus (cow) | 31,872 | 272 |
| dHV1 | 345790859 | 85.3 | Canis lupus familiaris (dog) | 31,216 | 268 |
| fHV1 | 355695395 | 82.8 | Mustela putorius furo (ferret) | 31,404 | 268 |
| EcHV1 | 338727680 | 79.0 | Equus caballus (horse) | 33,309 | 288 |
| mHV1 | 109809757 | 78.0 | Mus musculus (mouse) | 31,242 | 269 |
| rHV1 | 109497399 | 68.1 | Rattus norvegicus (Norway rat) | 33,737 | 294 |
| OcHV1 | 291406960 | 58.5 | Oryctolagus cuniculus (rabbit) | 43,090 | 391 |
| GgHV1 | 71897219 | 53.5 | Gallus gallus (chicken) | 27,599 | 235 |
| LaHV1 | 344297427 | 50.0 | Loxodonta africana (elephant) | 50,727 | 455 |
| XtHV1 | 56789050 | 45.6 | Xenopus (Silurana) tropicalis (Western clawed frog) | 26,575 | 230 |
| XlHV1 | 56788929 | 43.6 | Xenopus laevis (African clawed frog) | 26,596 | 230 |
| DrHV1 | 50539752 | 40.9 | Danio (Brachydanio) rerio (zebrafish) | 27,110 | 235 |
| CiHV1 | 118344228 | 26.1 | Ciona intestinalis (transparent sea squirt) | 38,501 | 342 |
| CsHV1 | 358341603 | 22.7 | Clonorchis sinensis (Chinese liver fluke) | 34,088 | 305 |
| SpHV1 | 187282419 | 22.3 | Strongylocentrotus purpuratus (purple sea urchin) | 37,483 | 328 |
| EhHV1 | JGI:631975 | 18.1 | Emiliania huxleyi (coccolithophore) | 37,389 | 339 |
| PtHV1 | 219120098 | 16.1 | Phaeodactylum tricornutum (diatom) | 38,582 | 338 |
| CvHV1 | 307105313 | 16.0 | Chlorella variabilis (green alga) | 50,746 | 480 |
| CpHV1 | 304359300 | 15.2 | Coccolithus pelagicus (coccolithophore) | 36,281 | 325 |
| kHV1 | 351694294 | 14.6 | Karlodinium veneficum (dinoflagellate) | 27,624 | 248 |
Characteristics of proton channel proteins are shown. The protein sequence identification (GI) numbers are from the NCBI database, the E. huxleyi number (JGI) is from the Joint Genome database, http://www.jgi.doe.gov/. Identity with the human protein is for full-length protein sequences, obtained from the “needle” option at http://www.ebi.ac.uk/Tools/emboss/align/ (EMBL-EBI). The isotopically averaged molecular mass of a monomer is given using Protein Calculator v 3.3 (http://www.scripps.edu/∼cdputnam/protcalc.html). Species for which the expressed gene product has been confirmed in voltage-clamp studies to function as a proton channel are in bold and include human (416), human Short form hHV1s (333), mouse and Ciona (432), purple sea urchin Strongylocentrotus (Y. Okamura, personal communication), two coccolithophores (489), a diatom Phaeodactylum tricornutum (488), and Karlodinium (462).