Fig. 1.

Teaching an old fly new tricks. A–C: Immune cells known as hemocytes were labeled with red fluorescent protein (RFP) and transplanted into flies expressing oncogenic Ras and/or lacking the tumor suppressor scrib. These hemocytes were only recruited to site of the transgene expression in Ras^V12;scrib tumors (Cordero et al., 2010). D–G: Oncogenic Ras^V12 and scrib loss of function synergize within a given clone to produce malignant over-growth and invasion into adjacent tissues. However, they may also synergize when present in adjacent clones (Wu et al., 2010). H–J: Wild-type (left) and l(3)mbt mutant (middle) tissue labeled with green fluorescent protein (GFP) were serially transplanted into the abdomen of adult hosts. Comparison of expression profiles showed l(3)mbt tumors were enriched for mRNA's of genes required for germline maintenance. Removal of some germline genes, such as piwi (right), abrogated tumor overgrowth (Janic et al., 2010). K,L: Overexpression of dRet^MEN2 in the fly eye results in dysplastic growth, reminiscent of tumors from the MEN2 cancer syndrome. Administration of a kinase inhibitor ZD6474 restores these eyes to a wild-type pattern (Vidal et al., 2005). This therapeutic has been validated for MEN2 patients.