Table 2.
Grade ≥ 2 Drug-Related Adverse Events
| Adverse Event | No. of Patients |
|
|---|---|---|
| Grade 2 | Grade 3 | |
| Abdominal pain/distension | 4 | |
| Alkaline phosphatase | 1 | |
| Anorexia | 5 | |
| Confusion | 1 | |
| Diarrhea | 12 | 2 |
| Dyspnea | 1 | |
| Fatigue | 2 | |
| Hand-foot skin reaction | 4 | |
| Headache | 4 | 1 |
| Heartburn/dyspepsia | 2 | |
| Hyperbilirubinemia | 3 | |
| Hypertension | 23 | 8 |
| Hypoalbuminemia | 2 | |
| Hypothyroidism | 15 | |
| Left ventricular systolic dysfunction | 1 | |
| Leukocytes | 1 | |
| Lymphopenia | 2 | 2 |
| Mucositis | 5 | |
| Neutropenia | 3 | 1 |
| Prolonged QTc interval | 1 | |
| Proteinuria | 15 | 1 |
| Rash | 3 | |
| Transaminitis | 6 | 4 |
| Tumor pain | 3 | 3 |
| Vomiting | 1 | |
| Weight loss | 8 | 1 |
NOTE. Worst grade is reported per patient; all adverse events were mapped to Common Terminology Criteria for Adverse Events (version 4.0).