Figure 4. Longitudinal imaging data in VX2 tumors infected with Ad-CMV-HA-SSTR2.

(a and c) Representative in vivo gamma camera planar images of VX2 tumors obtained at 5 days (a) and 2 weeks (c) after infection with Ad-CMV-HA-SSTR2 (S =  source of ¹¹¹In for positioning, i and ii are two different representative rabbits). (b and d) In vivo imaging derived biodistribution of ¹¹¹In-octreotide normalized to tumor weight (%ID/g) calculated with and without necrosis at 5 days (b) and 2 weeks (d) after infection with Ad-CMV-HA-SSTR2. Tumors infected with Ad-CMV-HA-SSTR2 by either IA or IT delivery consistently showed significantly higher levels of the radioligand uptake compared to tumors infected with control Ad-CMV-GFP (*, p<0.05 compared with GFP). (d) % ID/g without necrosis was significantly higher than % ID/g with necrosis in tumors infected with Ad-CMV-HA-SSTR2 in both IA and IT (#, p<0.01 for IA, n = 6 and p<0.01 for IT, n = 4) groups.