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. 2013 Jun 10;8(6):e65411. doi: 10.1371/journal.pone.0065411

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© 2013 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A–B show H&E staining of the sagittal sections of 2 weeks (2 wks) old control (A) and Smo tKO (B). Panel C–D show H&E staining of the sagittal sections of 3 wks old control (C) and Smo tKO (D). Panel E–F show H&E staining of the sagittal sections of 12 wks old control (E) and SmotKO (F). There are fewer chondrogenic cells (yellow arrow) in the tibial insertion site of patellar tendons in Smo tKO animals, and the tidemark of the Smo tKO mice is absent. See text for details. Yellow arrow = advanced differentiated cells. Blue arrow = tidemark. Scale bar = 100 µm.