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. Author manuscript; available in PMC: 2013 Jun 10.
Published in final edited form as: J Neurophysiol. 2004 Jul 14;92(5):2762–2770. doi: 10.1152/jn.00196.2004

FIG. 7.

FIG. 7

Baclofen inhibits NMDA receptor-mediated thalamocortical EPSCs. A: Time course showing the inhibition and recovery of EPSCs produced by bath application of 10 μM baclofen that were measured at + 60 mV in the presence of bicuculline and CNQX in a morphologically-identified layer IV inhibitory neuron. B: Averages of 10 consecutive EPSCs taken at the times indicated in A. C: The average NMDA receptor-mediated thalamocortical EPSC expressed as a percent of the control EPSC in cortical neurons (n = 4) before, during, and after (Wash) application of 10 μM baclofen. * p < 0.05. D: Concentration-response relationship of baclofen-mediated inhibition of thalamocortical EPSCs. All cells were recorded with intracellular Cs+ in the pipette.