Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2013 Jan 15;62:111–120. doi: 10.1016/j.freeradbiomed.2013.01.003

Fig 1. Mitochondrial dysfunction may lead to oxidative damage of macromolecules.

Fig 1

Genetic mutations or environmental factors inhibit complex I activity and/or result in mitochondrial impairment. Mitochondrial dysfunction produces ROS. The resultant ROS may damage macromolecules, including nucleic acids, lipids and proteins. An oxidized macromolecule can then damage another macromolecule, leading to a vicious cycle of oxidized products.